Drug profile
The FDA adverse-event record for Afoxolaner, Moxidectin, And Pyrantel
29 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Afoxolaner, Moxidectin, And Pyrantel. Species, reactions, and outcomes follow.
- #1464 of 2,679
- by report volume (all drugs)
- 29
- adverse-event reports
- 6.9%
- death-coded share
- Dog
- most-reported species
Corpus placement
According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Afoxolaner, Moxidectin, And Pyrantel ranks #1463 of 2679 by total reports (29). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).
- 149,624
- Milbemycin Oxime + Spinosad reports (#1)
- 97.8%
- Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
- #1463
- This drug, reports of 2679
Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.
Release-over-release change
What changed in the latest FDA data snapshot
PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Afoxolaner, Moxidectin, And Pyrantel has 29 reports now versus 25 in that prior snapshot: 4 more (16.0%).
- Report change
- +4
- Death-coded reports
- +0
- Death-coded share
- −1.1 pts
This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.
Subscribe to Afoxolaner, Moxidectin, And Pyrantel changesSignature read: death-coded report count at 2 is the most distinctive stamp on Afoxolaner, Moxidectin, And Pyrantel's FDA AER row.
Active Ingredients
Administration Routes
Species Affected
Most Affected Breeds
Most Reported Reactions
Outcome Breakdown
Afoxolaner, Moxidectin, And Pyrantel Adverse Event Insights
Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.
What to do with this drug
- Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
- Browse the full drug directory to compare report counts across products. All drugs
A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.
Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025
Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →