Drug profile

The FDA adverse-event record for Afoxolaner, Moxidectin, And Pyrantel

17 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Afoxolaner, Moxidectin, And Pyrantel. See the species affected, top reactions, and outcomes below.

17
adverse-event reports
11.8%
death-coded share
Dog
most-reported species
4
Abnormal radiograph finding - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
17
Total Reports
2
Deaths Reported
11.8%
Death Rate

Active Ingredients

Afoxolaner, Moxidectin, And Pyrantel

Administration Routes

OralUnknown

Species Affected

Dog 17

Most Affected Breeds

Beagle 2
Lhasa Apso 2
Retriever - Labrador 2
Shepherd Dog - German 2
Terrier - Bull - American Pit 2
Dog (unknown) 1
Greater Swiss Mountain Dog 1
Retriever (unspecified) 1
Boxer (German Boxer) 1
Great Pyrenees 1

Most Reported Reactions

Abnormal radiograph finding 4
Diarrhoea 3
Deafness 3
Vomiting 2
Hyperkalaemia 2
Low sodium-potassium ratio (Na:K ratio) 2
Decreased haemoglobin 2
Leucocytosis NOS 2
Increased urine concentration 2
Elevated protein:creatinine ratio 2
Active urine sediment 2
Adrenal gland tumour 2

Outcome Breakdown

Outcome Unknown
5 (29.4%)
Ongoing
5 (29.4%)
Recovered with Sequela
3 (17.6%)
Recovered/Normal
2 (11.8%)
Died
2 (11.8%)

Afoxolaner, Moxidectin, And Pyrantel Adverse Event Insights

17 reports name Afoxolaner, Moxidectin, And Pyrantel; 2 recorded a death outcome (11.8% of reported events, not a population-level mortality rate). Active ingredient: Afoxolaner, Moxidectin, And Pyrantel. Administration routes: Oral, Unknown.

By species: Dog (17 reports). By breed: Beagle (2), Lhasa Apso (2), Retriever - Labrador (2).

Leading clinical signs: Abnormal radiograph finding (4), Diarrhoea (3), Deafness (3), Vomiting (2). Outcome, 17 coded reports: Outcome Unknown leads at 29.4%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.