Drug profile

The FDA adverse-event record for Afoxolaner 75Mg / Moxidectin 360Mcg / Pyrantel 150Mg Chewable Tablet

2,159 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Afoxolaner 75Mg / Moxidectin 360Mcg / Pyrantel 150Mg Chewable Tablet. See the species affected, top reactions, and outcomes below.

2,159
adverse-event reports
1.4%
death-coded share
Dog
most-reported species
303
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
2,159
Total Reports
31
Deaths Reported
1.4%
Death Rate

Active Ingredients

Afoxolaner 75Mg / Moxidectin 360Mcg / Pyrantel 150Mg Chewable Tablet

Administration Routes

OralUnknownTopicalSubcutaneous

Species Affected

Dog 1,960
Unknown 198
Human 1

Most Affected Breeds

Retriever - Labrador 324
Unknown 199
Retriever - Golden 183
Crossbred Canine/dog 160
Pit Bull 119
Shepherd Dog - Australian 116
Shepherd Dog - German 100
Dog (unknown) 73
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 63
Collie - Border 53

Most Reported Reactions

Vomiting 303
Lack of efficacy (endoparasite) - heartworm 293
Lack of efficacy (endoparasite) - hookworm 245
Lack of efficacy (bacteria) - Borrelia 191
Tablets, Abnormal 181
Diarrhoea 167
Lack of efficacy (endoparasite) - roundworm NOS 147
Lethargy (see also Central nervous system depression in Neurological) 133
Lack of efficacy (endoparasite) - tapeworm 103
Seizure NOS 93
Lack of efficacy (ectoparasite) - flea 82
Lack of efficacy (ectoparasite) - tick NOS 67

Outcome Breakdown

Outcome Unknown
1,067 (54.4%)
Recovered/Normal
484 (24.7%)
Ongoing
379 (19.3%)
Died
17 (0.9%)
Euthanized
14 (0.7%)

Afoxolaner 75Mg / Moxidectin 360Mcg / Pyrantel 150Mg Chewable Tablet Adverse Event Insights

2,159 reports name Afoxolaner 75Mg / Moxidectin 360Mcg / Pyrantel 150Mg Chewable Tablet; 31 recorded a death outcome (1.4% of reported events, not a population-level mortality rate). Active ingredient: Afoxolaner 75Mg / Moxidectin 360Mcg / Pyrantel 150Mg Chewable Tablet. Administration routes: Oral, Unknown, Topical, Subcutaneous.

By species: Dog (1,960 reports), Unknown (198 reports), Human (1 reports). By breed: Retriever - Labrador (324), Unknown (199), Retriever - Golden (183).

Leading clinical signs: Vomiting (303), Lack of efficacy (endoparasite) - heartworm (293), Lack of efficacy (endoparasite) - hookworm (245), Lack of efficacy (bacteria) - Borrelia (191). Outcome, 1,961 coded reports: Outcome Unknown leads at 54.4%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.