Drug profile

The FDA adverse-event record for Afoxolaner 37.5Mg / Moxidectin 180Mcg / Pyrantel 75Mg Chewable Tablet

1,348 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Afoxolaner 37.5Mg / Moxidectin 180Mcg / Pyrantel 75Mg Chewable Tablet. See the species affected, top reactions, and outcomes below.

1,348
adverse-event reports
1.6%
death-coded share
Dog
most-reported species
313
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
1,348
Total Reports
21
Deaths Reported
1.6%
Death Rate

Active Ingredients

Afoxolaner 37.5Mg / Moxidectin 180Mcg / Pyrantel 75Mg Chewable Tablet

Administration Routes

OralUnknownTopicalPeriarticular

Species Affected

Dog 1,227
Unknown 116
Human 3
Cat 2

Most Affected Breeds

Unknown 119
Beagle 93
Retriever - Golden 88
Crossbred Canine/dog 68
Bulldog - French 67
Shepherd Dog - Australian 57
Dog (unknown) 54
Shih Tzu 48
Retriever - Labrador 46
Spaniel - King Charles Cavalier 45

Most Reported Reactions

Vomiting 313
Diarrhoea 150
Lack of efficacy (endoparasite) - hookworm 146
Lethargy (see also Central nervous system depression in Neurological) 126
Tablets, Abnormal 109
Lack of efficacy (endoparasite) - roundworm NOS 105
Lack of efficacy (bacteria) - Borrelia 90
Lack of efficacy (endoparasite) - heartworm 68
Seizure NOS 60
Lack of efficacy (ectoparasite) - flea 56
Itching 43
Lack of efficacy (endoparasite) - tapeworm 39

Outcome Breakdown

Outcome Unknown
626 (50.8%)
Recovered/Normal
416 (33.7%)
Ongoing
170 (13.8%)
Died
12 (1.0%)
Euthanized
9 (0.7%)

Afoxolaner 37.5Mg / Moxidectin 180Mcg / Pyrantel 75Mg Chewable Tablet Adverse Event Insights

1,348 reports name Afoxolaner 37.5Mg / Moxidectin 180Mcg / Pyrantel 75Mg Chewable Tablet; 21 recorded a death outcome (1.6% of reported events, not a population-level mortality rate). Active ingredient: Afoxolaner 37.5Mg / Moxidectin 180Mcg / Pyrantel 75Mg Chewable Tablet. Administration routes: Oral, Unknown, Topical, Periarticular.

By species: Dog (1,227 reports), Unknown (116 reports), Human (3 reports). By breed: Unknown (119), Beagle (93), Retriever - Golden (88).

Leading clinical signs: Vomiting (313), Diarrhoea (150), Lack of efficacy (endoparasite) - hookworm (146), Lethargy (see also Central nervous system depression in Neurological) (126). Outcome, 1,233 coded reports: Outcome Unknown leads at 50.8%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.