Drug profile

The FDA adverse-event record for Afoxolaner 2.27% Chewable Tablet (68 Mg)

272 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Afoxolaner 2.27% Chewable Tablet (68 Mg). See the species affected, top reactions, and outcomes below.

272
adverse-event reports
2.9%
death-coded share
Dog
most-reported species
71
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
272
Total Reports
8
Deaths Reported
2.9%
Death Rate

Active Ingredients

Afoxolaner 2.27% Chewable Tablet (68 Mg)

Administration Routes

OralUnknown

Species Affected

Dog 272

Most Affected Breeds

Crossbred Canine/dog 35
Dog (unknown) 23
Collie - Border 17
Spaniel - Cocker American 15
Retriever - Golden 12
Retriever - Labrador 11
Shepherd Dog - German 8
Bulldog - French 8
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 6
Spaniel - Cocker English 6

Most Reported Reactions

Vomiting 71
Skin disorders NOS 45
Pruritus 43
Diarrhoea 30
Lack of efficacy (ectoparasite) - tick NOS 27
Lack of efficacy (ectoparasite) - flea 24
Lethargy (see also Central nervous system depression in 'Neurological') 19
Erythema (for urticaria see Immune SOC) 15
Anorexia 14
Panting 11
Seizure NOS 11
Scratching 11

Outcome Breakdown

Recovered/Normal
136 (50.0%)
Outcome Unknown
109 (40.1%)
Ongoing
19 (7.0%)
Died
5 (1.8%)
Euthanized
3 (1.1%)

Afoxolaner 2.27% Chewable Tablet (68 Mg) Adverse Event Insights

272 reports name Afoxolaner 2.27% Chewable Tablet (68 Mg); 8 recorded a death outcome (2.9% of reported events, not a population-level mortality rate). Active ingredient: Afoxolaner 2.27% Chewable Tablet (68 Mg). Administration routes: Oral, Unknown.

By species: Dog (272 reports). By breed: Crossbred Canine/dog (35), Dog (unknown) (23), Collie - Border (17).

Leading clinical signs: Vomiting (71), Skin disorders NOS (45), Pruritus (43), Diarrhoea (30). Outcome, 272 coded reports: Recovered/Normal leads at 50.0%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.