Drug profile

The FDA adverse-event record for Afoxolaner 18.75Mg / Moxidectin 90Mcg / Pyrantel 37.5Mg Chewable Tablet

1,113 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Afoxolaner 18.75Mg / Moxidectin 90Mcg / Pyrantel 37.5Mg Chewable Tablet. See the species affected, top reactions, and outcomes below.

1,113
adverse-event reports
1.9%
death-coded share
Dog
most-reported species
297
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
1,113
Total Reports
21
Deaths Reported
1.9%
Death Rate

Active Ingredients

Afoxolaner 18.75Mg / Moxidectin 90Mcg / Pyrantel 37.5Mg Chewable Tablet

Administration Routes

OralUnknown

Species Affected

Dog 1,025
Unknown 87
Human 1

Most Affected Breeds

Shih Tzu 103
Chihuahua 101
Unknown 89
Dog (unknown) 83
Terrier - Yorkshire 65
Dachshund (unspecified) 47
Retriever - Golden 42
Maltese 42
Beagle 40
Poodle - Miniature 36

Most Reported Reactions

Vomiting 297
Diarrhoea 128
Lethargy (see also Central nervous system depression in Neurological) 114
Lack of efficacy (endoparasite) - hookworm 92
Lack of efficacy (bacteria) - Borrelia 74
Tablets, Abnormal 65
Lack of efficacy (ectoparasite) - flea 63
Seizure NOS 57
Lack of efficacy (endoparasite) - roundworm NOS 54
Not eating 40
Itching 35
Lack of efficacy (bacteria) - Anaplasma 30

Outcome Breakdown

Outcome Unknown
526 (51.3%)
Recovered/Normal
362 (35.3%)
Ongoing
115 (11.2%)
Died
15 (1.5%)
Euthanized
6 (0.6%)
Recovered with Sequela
2 (0.2%)

Afoxolaner 18.75Mg / Moxidectin 90Mcg / Pyrantel 37.5Mg Chewable Tablet Adverse Event Insights

1,113 reports name Afoxolaner 18.75Mg / Moxidectin 90Mcg / Pyrantel 37.5Mg Chewable Tablet; 21 recorded a death outcome (1.9% of reported events, not a population-level mortality rate). Active ingredient: Afoxolaner 18.75Mg / Moxidectin 90Mcg / Pyrantel 37.5Mg Chewable Tablet. Administration routes: Oral, Unknown.

By species: Dog (1,025 reports), Unknown (87 reports), Human (1 reports). By breed: Shih Tzu (103), Chihuahua (101), Unknown (89).

Leading clinical signs: Vomiting (297), Diarrhoea (128), Lethargy (see also Central nervous system depression in Neurological) (114), Lack of efficacy (endoparasite) - hookworm (92). Outcome, 1,026 coded reports: Outcome Unknown leads at 51.3%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.