Drug profile

The FDA adverse-event record for Afoxolaner 150Mg / Moxidectin 720Mcg / Pyrantel 300Mg Chewable Tablet

1,747 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Afoxolaner 150Mg / Moxidectin 720Mcg / Pyrantel 300Mg Chewable Tablet. See the species affected, top reactions, and outcomes below.

1,747
adverse-event reports
1.9%
death-coded share
Dog
most-reported species
273
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
1,747
Total Reports
34
Deaths Reported
1.9%
Death Rate

Active Ingredients

Afoxolaner 150Mg / Moxidectin 720Mcg / Pyrantel 300Mg Chewable Tablet

Administration Routes

OralUnknownParenteralPerineural

Species Affected

Dog 1,556
Unknown 191

Most Affected Breeds

Retriever - Labrador 348
Shepherd Dog - German 196
Unknown 191
Retriever - Golden 180
Dog (unknown) 134
Pit Bull 66
Great Pyrenees 51
Crossbred Canine/dog 51
Mountain Dog - Bernese 46
Boxer (German Boxer) 40

Most Reported Reactions

Vomiting 273
Lack of efficacy (endoparasite) - heartworm 209
Tablets, Abnormal 193
Diarrhoea 148
Lack of efficacy (bacteria) - Borrelia 146
Lethargy (see also Central nervous system depression in Neurological) 136
Lack of efficacy (endoparasite) - hookworm 121
Seizure NOS 95
Lack of efficacy (endoparasite) - tapeworm 85
Lack of efficacy (endoparasite) - roundworm NOS 77
Itching 69
Lack of efficacy (bacteria) - Anaplasma 62

Outcome Breakdown

Outcome Unknown
858 (55.1%)
Recovered/Normal
399 (25.6%)
Ongoing
265 (17.0%)
Died
21 (1.3%)
Euthanized
13 (0.8%)

Afoxolaner 150Mg / Moxidectin 720Mcg / Pyrantel 300Mg Chewable Tablet Adverse Event Insights

1,747 reports name Afoxolaner 150Mg / Moxidectin 720Mcg / Pyrantel 300Mg Chewable Tablet; 34 recorded a death outcome (1.9% of reported events, not a population-level mortality rate). Active ingredient: Afoxolaner 150Mg / Moxidectin 720Mcg / Pyrantel 300Mg Chewable Tablet. Administration routes: Oral, Unknown, Parenteral, Perineural.

By species: Dog (1,556 reports), Unknown (191 reports). By breed: Retriever - Labrador (348), Shepherd Dog - German (196), Unknown (191).

Leading clinical signs: Vomiting (273), Lack of efficacy (endoparasite) - heartworm (209), Tablets, Abnormal (193), Diarrhoea (148). Outcome, 1,556 coded reports: Outcome Unknown leads at 55.1%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.