Drug profile

The FDA adverse-event record for Advantix

12 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Advantix. See the species affected, top reactions, and outcomes below.

12
adverse-event reports
16.7%
death-coded share
Dog
most-reported species
3
Lack of efficacy (bacteria) - Borrelia - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
12
Total Reports
2
Deaths Reported
16.7%
Death Rate

Active Ingredients

Advantix

Administration Routes

UnknownTopicalOral

Species Affected

Dog 12

Most Affected Breeds

Retriever - Labrador 2
Chihuahua 1
Shih Tzu 1
Terrier - Boston 1
Rottweiler 1
Terrier - Jack Russell 1
Terrier - Bull 1
Shepherd Dog - German 1
Shepherd Dog - Australian 1
Terrier - Yorkshire 1

Most Reported Reactions

Lack of efficacy (bacteria) - Borrelia 3
Seizure NOS 2
Not eating 2
Death by euthanasia 2
Behavioural disorder NOS 2
Lack of efficacy (ectoparasite) - tick NOS 1
Itching 1
Retching 1
Foaming at the mouth 1
Shaking 1
Stiffness NOS 1
Polycythaemia 1

Outcome Breakdown

Ongoing
8 (66.7%)
Outcome Unknown
2 (16.7%)
Euthanized
2 (16.7%)

Advantix Adverse Event Insights

12 reports name Advantix; 2 recorded a death outcome (16.7% of reported events, not a population-level mortality rate). Active ingredient: Advantix. Administration routes: Unknown, Topical, Oral.

By species: Dog (12 reports). By breed: Retriever - Labrador (2), Chihuahua (1), Shih Tzu (1).

Leading clinical signs: Lack of efficacy (bacteria) - Borrelia (3), Seizure NOS (2), Not eating (2), Death by euthanasia (2). Outcome, 12 coded reports: Ongoing leads at 66.7%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.