Drug profile
The FDA adverse-event record for Advantage Multi
58 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Advantage Multi. See the species affected, top reactions, and outcomes below.
- 58
- adverse-event reports
- 5.2%
- death-coded share
- Dog
- most-reported species
- 41
- Lack of efficacy (endoparasite) - heartworm - top reaction
Active Ingredients
Administration Routes
Species Affected
Most Affected Breeds
Most Reported Reactions
Outcome Breakdown
Advantage Multi Adverse Event Insights
58 reports name Advantage Multi; 3 recorded a death outcome (5.2% of reported events, not a population-level mortality rate). Active ingredient: Advantage Multi. Administration routes: Topical, Unknown, Oral.
By species: Dog (54 reports), Cat (4 reports). By breed: Retriever - Labrador (6), Chihuahua (5), Crossbred Canine/dog (4).
Leading clinical signs: Lack of efficacy (endoparasite) - heartworm (41), Overdose (4), Decreased appetite (4), Elevated total bilirubin (4). Outcome, 58 coded reports: Ongoing leads at 70.7%.
Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.
Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.